Background Postmenopausal estrogen decline is implicated in several age-related physical and psychological changes in women, including decreases in perceived quality of life (QoL). A number of trials with hormone therapy showed beneficial effects of the intervention on parameters of quality of life. However, because of known or suspected serious side-effects of conventional hormone therapy there is a need for alternatives
Objectives The goal of this study was to evaluate the effect of genistein treatment on health-related quality of life in osteopenic postmenopausal women.
Methods We conducted a double-blind randomized placebo-controlled trial with phytoestrogen genistein 54 mg or placebo for 2 year. For this trial, we recruited 288 postmenopausal women aged 49 to 67 years. At baseline, after 1 year and at final visit, participants filled in the Short Form of 36 questions (SF-36), the Questionnaire on Life Satisfaction Modules (QLSM), and the Zung Self-Rating Depression Scale (ZSDS).
Results For the placebo group scores on all dimensions of the SF-36 and the QLSM decreased after 1 year and after 2 years. The genistein group showed increases on all dimensions of the SF-36 and the QLSM. There were however statistically significant differences in changes of scores between the two intervention groups. For the ZSDS similarly, significant differences were found between the groups.
Conclusions In conclusion, the findings in this randomized trial do support the presence of a marked effect of phytoestrogen genistein on quality of life (health status, life satisfaction, and depression) in osteopenic postmenopausal women.
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Disclosure of Interest None Declared