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AB1042 Synergistic effect of NSAIDS in bisphosphonate treatment, compared to COX-2 inhibitor
  1. S.Y. Lee1,
  2. S.W. Lee1,
  3. W.T. Chung1,
  4. C.W. Lee2,
  5. E.J. Kang3
  1. 1Rheumatology of Internal Medicine, Dong-A University Hospital
  2. 2Rheumatology of Internal Medicine, Bapist hospital
  3. 3Rheumatology of Internal Medicine, Pusan medical hospital, Pusan, Korea, Republic Of


Background In humans, NSAIDs appear to slow bone loss in periodontal disease by inhibiting synthesis of prostaglandins, known stimulators of osteoclastic resorption. This suggest a possible clinical application for NSAIDs in prevention of bone loss

Objectives To investigate the bisphosphonate effects on bone mineral density and T-score in NSAIDs used Patients, compared to COX-2 inhibitor used group

Methods Between January 2005 and September 2011, 319 women and 104 men were enrolled who were osteoarthritis or rheumatoid arthritis(taken below prednisolone 5mg) with osteoporosis, treated with NSAIDs or COX-2 inhibitors. The subjects were taken bisphosphonate and bone mineral density was measured by Dual-emission absorptiometry every one year. We observed the difference of bone mineral density, T-Score in NSAIDs and COX-2 used groups, spacing 2 years

Results The efficacy of bisphosphonate on bone mineral density and T-Score was better in NSAIDs group than COX-2 inhibitors group (P<0.05). other factros were not affected to bone mineral density and T-Score in both groups

Conclusions In our single center study, we observed the combination bisphosphonate with NSAIDs was better response in osteoporosis treatment than COX-2 inhibitors. Further multicenter studies are needed to confirm our results

  1. Journal of Bone and Mineral Research, Volume 13, Number 12, 1998

  2. Osteoporos Int (2006) 17:1410–1419

Disclosure of Interest None Declared

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