Background Evaluating the effectiveness of the treatment of knee osteoarthritis with hyaluronic acid (Suplasyn).
Objectives Evaluate the effectiveness of intra-articular injections of hyaluronic acid (Suplasyn) in patients with knee osteoarthritis in different age groups, given the stage and duration of the disease.
Methods We conducted a parallel study for 2 years in 87 patients with knee osteoarthritis. In making a diagnosis using clinical-ray study (X-ray, MRI). Patients were divided into 2 groups.
The first group included 25 women, 19 men with symptomatic and radio logically confirmed knee osteoarthritis stages I-II disease. Patients at the age of 51 to 60 years old. Disease duration of 1.5 to 3 years.
The second group included 26 women, 17 men with symptomatic and radio logically confirmed knee osteoarthritis stage III-IV disease. At the age of 61 to 70 years. Disease duration from 3 to 8 years.
Injections of 2.0 ml (20 mg/ml), HA (Suplasyn) used once every 7 days for 3 consecutive weeks. Then after 8-10 months of treatment was repeated again in the same way. Evaluating the effectiveness of treatment was assessed by visual analog scale (VAS) and Leqesne Algo-functional index for knee osteoarthritis (Leqesne M.G., 1997).
Results After 1 year of treatment, the study in both groups showed pain reduction, improved function of knee joints and improve the quality of life. In group I to the first treatment rate was (VAS) averages of 3.5, after treatment was 0.5. Index Leqesne before treatment was 5.4, after treatment was 1.5. In Group II to the first treatment rate was equal to (VAS) average of 7.5 after treatment was equal to 6.2. Index Leqesne before treatment was 11, after treatment was 8. After 2 courses of treatment, the study in both groups showed a slight decrease pain and improves knee function. In group I to the second course of treatment rate was equal to the VAS average of 1.5 after treatment was 0.5. Index Leqesne composes 3.0 before treatment after treatment was 1.0. In Group II to the second treatment was VAS figure is an average of 7.9 after treatment was equal to 6.4. Index Leqesne before treatment was 12, after treatment was 8.5.
Treatment of Suplasyn in the first group showed greater efficiency as compared to the second group after the first and second course of treatment.
Conclusions Injections of Suplasyn most effective in reducing pain and improving function in the knee joints in patients between 51 and 60 years old for stages I and II disease with a disease duration of 1.5 to 3 years.
Petrella R.J. Petrella M. A Prospective, Randomized, Double-Blind, Placebo controlled study to Evaluate the Efficacy of Intraarticular Hyaluronic Acid for Osteoarthritis of the Knee. The Journal of Rheumatology 2006; 33:5.
Petrella R.J. Hyaluronic acid for the treatment of knee osteoarthritis: Long-term outcomes from a naturalistic primary care experience. Am J Phys Med 2005;84:278-83.
Disclosure of Interest None Declared
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