Background Lypopolysaccharides (LPS)- induced cartilage damage is widely used as a model to investigate the effectiveness of cartilage protective agents in vitro. Overwhelming liver LPS of intestinal origin break impaired liver barriers, achieve blood stream in low but sustained accounts and spread to joints. That results in lipopolysaccharide (LPS) - binding protein (LBP) - CD14(TLR-4) activation of inflammatory response and development of degenerative joints changes (osteophyte formation and cartilage loss). Easy penetration of LPS into circulation may be a result from liver dysfunction associated with fatty liver. We proposed an analogical in vivo model of bone degenerative changes related to fatty liver.
Objectives To assess a size of spinal osteophytes in patients with fatty liver in comparison to spinal osteophytes in normal liver control group.
Methods Ultrasound (US) images of patients admitted to the emergency department for abdominal pain were revised. Two subgroups of patients of similar age and gender were compared: 26 patients (13 male, mean age of 56.2±8.5 years) with US features of fatty liver and 26 patients (13 male, mean age 57.5±8.0 years, p=0.56) without US features of fatty liver. Retrospective analysis of images of the spine (X-ray, CT) in both populations obtained from the hospital imaging data base, was performed. Four maximal size spinal osteophytes were measured. In order to reduce an influence of individual body size factors the spine osteophyte radial length/vertebral width (O/V) ratio was calculated. Correlation between osteophytes’ size, patient age, and Body Mass Index (BMI) in both subgroups was assessed.
Results Spine osteophytes of patients with fatty liver had a bigger size (O/V=0.21±0.06) compared with patients with normal liver (O/V=0.14±0.03, p<0.0001). Fatty liver patients had a higher BMI (32.7±5.4kg/m2) compared to normal liver patients (28.0±6.7kg/m2, p=0.031). In order to distinguish an influence of BMI and fatty liver on O/V, patients of normal liver group were divided according to increased BMI (>25kg/m2) and normal one (<25kg/m2). O/V of both groups showed similar values: 0.14±0.03 and 0.13±0.02 respectively (p=0.52). BMI of the groups was significantly different: 31.8±5.4 (>25kg/m2) and 21.3±1.7 (normal) (p<0.001). No correlation was found between O/V and BMI in fatty liver group and normal (p=o.81, p=0.51, respectively). In opposite, significant O/V and age correlation was found in normal liver group (p=0.014) and weak correlation in the fatty liver group (p=0.063).
Conclusions Fatty liver may be considered as a predisposing factor in the pathogenesis of spine osteophytosis.
Disclosure of Interest None Declared