Background Metabolic syndrome (MetS) is regarded as one of the extraarticular manifestations of psoriasis (Pso) and psoriatic arthritis (PsA). Its etiology is as yet not well understood. The major component of MetS is insulin resistance, which is, among others associated with chronic inflammation . So we put a question, if chronic inflammation in active PsA could contribute to the development of the MetS.
Objectives To ascertain if the occurrence of MetS is associated with higher clinical or humoral activity of the disease.
Methods 103 consecutive patients with PsA were followed for two years and their clinical activity was assessed clinically using ``disease activity index in PsA``(DAPsA)  and humoral activity through C-reactive protein (CRP) twice a year for 2 – 4 years. The parameters of MetS were checked once a year. So we had 4 – 6 controls available. The pats were dividend in two groups: those with MetS (MetS+) and without MetS (MetS-). Then the average values of DAPsA and CRP in both groups were calculated and compared.
Results The average values of DAPsA, as well as CRP did not differ substantially in both groups - see table 1.
Conclusions On the basis of this study we cannot confirm the association of the activity of PsA as assessed clinically or using laboratory parameter (CRP).The drawback of this small, preliminary study is that it did not take into account the severity of psoriasis and the pharmacotherapy.
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Schoels M, Aletaha D, Funovits J, et al. Application of the DAREA/DAPSA score for assessment of disease activity in psoriatic arthritis. Ann Rheum Dis 2010;69:1441-1447
Disclosure of Interest J. Stolfa Grant/Research support from: Supported by Ministery of Health of Czech Republic Grant Number 000 000 23728