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AB0883 Evaluating patient-reported outcomes in patients with early spondyloarthritis in the desir cohort
  1. G.H. Louie1,
  2. D. van der Heijde2,
  3. M. Dougados3,4,
  4. C.O. Bingham1
  1. 1Rheumatology, Johns Hopkins University, Baltimore, United States
  2. 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands
  3. 3Rheumatology, Paris-Descartes University
  4. 4Rheumatology, Cochin Hospital, Paris, France

Abstract

Background Most patient-reported outcomes (PROs) for spondyloarthritis (SpA) were developed in ankylosing spondylitis (AS) and concentrate on pain and function. Disease-specific PROs are not well-studied in patients (pts) with early inflammatory back pain (IBP). DESIR (DEvenir Spondyloarthropathies Indifferenciées Récentes) is a French multicenter, prospective longitudinal cohort study of pts (n=708) with early IBP (Cailin or Berlin criteria) and 3-35 mos of SpA symptoms by investigator assessment (≥5 on 0-10 scale; 0=no suggestion, 10=high suggestion).

Objectives To examine existing SpA PROs in pts with early IBP.

Methods Using DESIR, we tested correlations of baseline (BL) scores on disease-specific PROs in early SpA [Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and Bath Ankylosing Spondylitis Functional Index (BASFI)] using Pearson’s correlation coefficients. We then analyzed BL scores by pt subgroups (e.g. peripheral arthritis, enthesitis, uveitis, psoriasis (PsO), anterior chest wall pain, and inflammatory bowel disease (IBD)).

Results Among 708 early SpA pts (mean age 33.8±8.6 yrs, 46.2% men, 57.9% HLA-B27 positive, mean symptoms 18.4±11.2 mos) mean BL ASQoL, BASDAI, and BASFI were 9.3±5.0, 4.5±2.0, and 3.0±2.4, respectively. Correlations between BL ASQoL, BASDAI, and BASFI ranged from r=0.68-0.70. Higher scores on the 3 instruments were observed in pts with peripheral arthritis, enthesitis, PsO, anterior chest wall pain, and IBD than in patients without these SpA clinical features (Table). Lower scores on the PROs were observed in pts with uveitis than in those without.

Table 1. Baseline scores (mean ± SD) on the ASQoL, BASDAI, and BASFI based on the presence (+) or absence (–) of SpA features

Conclusions The modest correlations between the different PROs (e.g. ASQoL, BASDAI, BASFI) suggest that these PROs are evaluating different facets or aspects of the patients’ condition. Moreover, this study suggests also that the impact of the disease on the patients’ condition is similar across the different clinical sub-groups of the SpA disease.

Disclosure of Interest None Declared

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