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AB0871 Effect of cigarette smoking in chinese patients with ankylosing spondylitis
  1. C.T. Chou1,
  2. C.H. Chen2,
  3. H.A. Chen3,
  4. H.T. Liao4,
  5. C.H. Liu2
  1. 1Allergy -Immunology-Rheumatology, Veterans General Hospital Taipei
  2. 2Allergy -Immunology-Rheumatology, Buddhist Tzu Chi General Hospital Taipei, Taipei
  3. 3Allergy -Immunology-Rheumatology, Chi Mei Medicaal Center, Tainan
  4. 4Allergy -Immunology-Rheumatology, Wang Fang Hospital, Taipei, Taiwan, China

Abstract

Background Accumulating evidence showed smoking has been associated with inflammation and play a pivotal role in the development of RA.

Objectives To investigate whether the smoking has an association with ankylosing spondylitis (AS) on disease activity, functional ability and physical mobility in Chinese patients.

Methods Seventy-five Chinese male AS patients in Taiwan were enrolled in the cross-sectional study. Patients completed the questionnaires, containing BASDAI, BASFI and BAS-G. Meanwhile, physical examinations were performed, including lumbar flexion (modified Schober index, MSI), intermalleolar distance (IMD), cervical rotation (CR), lateral lumbar flexion (LLF), fingertip-to-floor distance (FFD), chest expansion (CE) and occiput-to-wall distance (OWD). Smoking habit included smoking duration, and smoking intensity (pack-years of smoking)

Results Among the physical mobility parameters, MSI (p<0.001), CR (p=0.034), LLF (p=0.002) and CE (p=0.016) were significantly reduced in the AS patients with smoking as compared to those with non-smoking. OWD was significantly increased in the patients with smoking than those with non-smoking (p=0.003). ESR was significantly higher in the AS patients with smoking than those with non-smoking (p=0.03). Among the 35 smoking AS patients, smoking intensity significantly correlated with BASFI (r =0.481, p=0.005), CR (r = -0.401, p=0.031), FFD (r =0.485, p=0.004), and OWD (r =0.473, p=0.005).

Conclusions The cigarette smoking is associated systemic inflammation, and poor physical mobility in Chinese AS patients, and quit smoking is an important recommendation for AS patients.

Disclosure of Interest None Declared

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