Background Systemic sclerosis (SSc) may lead to pulmonary artery hypertension. Brain natriuretic peptide (BNP), a marker of cardiac failure, is a diagnostic marker of early pulmonary arterial hypertension (PAH) in patients with SSc. Obesity promotes a relative BNP deficiency because insulin resistance is associated with lower BNP level. So our aim was to analyzed affection of the body mass index (BMI) in level of BNP in screening for PAH in SSc
Objectives To analyzed affection of BMI in level of BNP in screening for PAH in SSc
Methods Between January 2010 and september 2011, outpatients referred to our unit and satisfying LeRoy criteria for SSc were assessed for PAH. Doppler echocardiography, BNP measurement, and BMI measurement were done concomitantly for a complete clinical, instrumental, and biochemical evaluation. Right-heart catheterization was carried out in cases of PAH
Results Twenty-nine patients were enrolled (23 women, 6 men; 4 limited SSc, 25 diffuse SSc); precapillary PAH was found in 2 patients (0 limited SSc, 2 diffuse SSc). All subjects were divided into three group: Group A, BMI<25 (n=25); Group B, BMI 25 to 30 (n=3), and Group C, BMI>30 (n=1). Group A: increased with BNP. while BNP decreased in group C. The estimated PAP correlated with BNP (R =0.3; 95% CI 0.14–0.44) but not with BMI (R =0.7, 95% CI 0.14–1.45). BNP (p=0.032) and creatinine (p=0.049) were independent predictors of PAH, while BMI was not (p=0.50).
Conclusions In our single-center study, Low BMI was correlation with high BNP in SSC. So BMI affected the level of BNP in PAH of SSC.
Prevalence of Exercise Pulmonary Arterial Hypertension in Scleroderma. Jose Luis Callejas-Rubio, Eduardo Moreno-Escobar, Pilar Martín de la Fuente, Lourdes Lόpez Pérez, Raquel Rios Fernández, Daniel Sánchez-Cano, José Pomares Mora, Norberto Ortego-Centeno, July 15 2008; J Rheumatol 2008;35:1812–6.
Disclosure of Interest None Declared