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AB0730 Kikuchi-fujimoto disease: Past and future dangerous liaisons
  1. V. Ortiz-Santamaria1,
  2. B. Consola2,
  3. J. Sanchez-Manubens3,
  4. M.T. Coll4,
  5. M. Bernet5,
  6. A. Villagrasa2,
  7. J. Cuquet2,
  8. E. Llargués2,
  9. X. Surís1
  1. 1Rheumatology
  2. 2Internal Medicine
  3. 3Pediatrics, Granollers General Hospital, Barcelona
  4. 4Pediatrics, Granollers General Hospital, Granollers. Barcelona
  5. 5Pathologist, Granollers General Hospital, Barcelona, Spain

Abstract

Background Kikuchi-Fujimoto disease (KFD) is known as histiocytic necrotizing lymphadenitis. The most important signs and symptoms are cervical lymph node enlargement and fever. This disease is usually benign and self-limiting. The cause of this disease is not known, although infectious and autoimmune etiologies such as Systemic Lupus Erythematosus (SLE) have been proposed.

Objectives To report clinical manifestations, laboratory findings and follow-up of patients with Kikuchi-Fujimoto disease.

Methods We report 4 cases of KFD collected in a county hospital. The observation period was 1990-2010. The reference area had a population of 300.000 inhabitants. We analyzed the clinical features, laboratory findings, clinical course and its relation to SLE.

Results The cases of KFD included 4 females with an average age of 23 years old (13-40) at the time of the diagnosis (see Table).

One of the patients (case 3) presented at an unusually young age with atypical lymph-node localization: supraclavicular, inguinal and axillary.

During follow-up, we confirmed the diagnosis of SLE in 2 patients. These diagnoses changed the therapeutic strategy in these cases. The other 2 cases are being monitored closely, due to the high probability that they will develop an autoimmune disease.

Conclusions The importance of a diagnosis of KFD lies in the possible association with an autoimmune disease.

KFD can precede, coincide or appear during the development of autoimmune diseases, usually SLE.

A diagnosis of KFD requires histological confirmation.

Disclosure of Interest None Declared

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