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AB0710 Histological evaluation of enlarged submandibular glands in the diagnosis of systemic diseases
  1. S. Sedyshev1,
  2. V. Vasilyev1,
  3. I. Gayduk2,
  4. A. Kovrigina3,
  5. O. Logvinenko1,
  6. A. Borovskaya2
  1. 1Research Institute of Rheumatology of Rams
  2. 2Msmsu
  3. 3Hematological Research Centre, Moscow, Russian Federation

Abstract

Objectives To evaluate the diagnostic of histological and immunomorphological studies of enlarged submandibular salivary glands (SSG) in the diagnosis of systemic diseases.

Methods We examined 14 patients (male – 4, female - 10), mean age - 52.4 years (26 - 76) with unilateral or bilateral enlargement of SSG. All the patients were taken samples of SSG tissue. The applied techniques were extirpation of the SSG (n=8), incisional biopsy (n=3), needle biopsy (n=2), autopsy (n=1). In all cases histological and immunomorphological examination of SSG tissue. Eleven patients had xerostomia. Sialography showed parenchymal sialadenitis in 3 patients. Six patients had markers of autoimmune diseases (rheumatoid factor, antinuclear antibodies, anti-SSA, anti-SSB, ACCP, hypergammaglobulinemia), 4 – had signs of acute inflammation (CRP, elevated ESR).

Histological study of enlarged submandibular salivary glands, especially when using a minimally invasive incisional biopsy, is a useful and informative method of diagnosing a wide range of systemic diseases.

Results Most patients are sent for examination with suspected primary Sjögren’s syndrome (n=6), sclerosing sialadenitis (n=4) or primary NHL (n=2). While the survey the initial diagnosis was withdrawn in 13 patients. On the basis of clinical, laboratory, histological and immunomorphological examination 6 patients were diagnosed with IgG4-RSD (Mikulicz’s disease (n=2), Küttner’s tumor (n=1), multifocal fibrosclerosos (n=2). In 7 cases various lymphoproliferative disease were diagnosed (MALT-lymphoma+rheumatoid arthritis (n=3), MALT-lymphoma+ pSS (n=1), primary AL-amyloidosis (n=2) and primary NHL (n=1). Generalized sarcoidosis was shown in 1 patient.

Conclusions Histological study of enlarged submandibular salivary glands, especially when using a minimally invasive incisional biopsy, is a useful and informative method of diagnosing a wide range of systemic diseases.

Disclosure of Interest None Declared

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