Background Premature atherosclerosis had been observed in Systemic Lupus Erythematosus (SLE) patients,  but the reason for this accelerated process is still debatable  although traditional risk factors are more prevalent in those patients than general population, they do not seem to fully explain that enhanced risk . In SLE mexicans we do not have enough information.
Objectives To recognize premature atherosclerosis in Mexican SLE patients, through carotid ultrasound.
Methods We did an observational, descriptive, cross-sectional study in mexican population, between 2 groups (69 SLE patients and 69 age-sex-diabetes-hypertension- matched subjects), realized biochemical and anthropometric measurements, and carotid ultrasound.
Results We found a statistically significant higher prevalence of thickness in both internal carotid arteries, but we did not found association between carotid plaque and hypertension, diabetes or any cardiovascular risk factor.
Conclusions Hence a multi-targeted approach to treatment which addresses both lupus-specific factors as well as the associated traditional cardiovascular risks is important to further reduce the burden of cardiovascular disease among our Mexican SLE patients.
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Disclosure of Interest None Declared