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AB0672 Carotid atherosclerosis in mexicans with systemic lupus erythematosus
  1. I.J. Colunga-Pedraza1,
  2. D.A. Galarza-Delgado1,
  3. F. Gόngora-Rivera2,
  4. S.L. Segarra-Linares3,
  5. M.A. Garza-Elizondo1
  1. 1Rheumatology
  2. 2Neurology, Hospital Universitario
  3. 3Facultad de Medicina UANL, Monterrey, Mexico

Abstract

Background Premature atherosclerosis had been observed in Systemic Lupus Erythematosus (SLE) patients, [1] but the reason for this accelerated process is still debatable [2] although traditional risk factors are more prevalent in those patients than general population, they do not seem to fully explain that enhanced risk [3]. In SLE mexicans we do not have enough information.

Objectives To recognize premature atherosclerosis in Mexican SLE patients, through carotid ultrasound.

Methods We did an observational, descriptive, cross-sectional study in mexican population, between 2 groups (69 SLE patients and 69 age-sex-diabetes-hypertension- matched subjects), realized biochemical and anthropometric measurements, and carotid ultrasound.

Results We found a statistically significant higher prevalence of thickness in both internal carotid arteries, but we did not found association between carotid plaque and hypertension, diabetes or any cardiovascular risk factor.

Table 1. Comparison of demographic characteristics between our two groups of study

Table 2. Comparison of carotid ultrasound values

Conclusions Hence a multi-targeted approach to treatment which addresses both lupus-specific factors as well as the associated traditional cardiovascular risks is important to further reduce the burden of cardiovascular disease among our Mexican SLE patients.

  1. Thomas GN, Tam LS, Tomlinson B, Li EK.Accelerated atherosclerosis in patients with systemic lupus erythematosus: a review of the causes and possible prevention. Hong Kong Med J. 2002 Feb;8(1):26-32.

  2. Bruce IN. “Not only ... but also”: factors that contribute to accelerated atherosclerosis and premature coronary heart disease in systemic lupus erythematosus. Rheumatology (Oxford).2005 Dec;44(12):1492-502.

  3. Esdaile JM, Abrahamowicz M, Grodzicky T, Li Y, Panaritis C, du Berger R,et al.Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum.2001 Oct;44(10):2331-7.

Disclosure of Interest None Declared

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