Background Primary Sjogren’s syndrome (pSS) is characterised by diminished exocine glandular functions caused by autoimmune epithelitis due to dysregulated immune response. Low vitamin D level might be one of its etiologic factors.
Objectives The aim of this cross-sectional study was to evaluate 25 hydroxy D vitamin status in a cohort of Hungarian patients with pSS.
Methods European-American consensus criteria were used to identify pSS patients. 25-hydroxyvitamin D (25OH D) was measured by a direct competitive chemiluminescent immunoassay. Anti-SS-A, anti-SS-B and rheumatoid factor (RF) were assessed with routine laboratory methods. Appropriate statistical tests were used to analyse association between 25OH D level and clinical as well as laboratory parameters.
Results The mean ages of the 54 pSS female patients was 58.6±13.92 years. Anti- SS-A, anti-SS-B and RF was present in 33, 26 and 17 patients. Arthritis, vasculitis, CNS or PNS manifestations and autoimmune thyreoiditis occurred in 37, 10, 8, 14 and 17 patients, respectively. The concentration of 25OH D (mean±SD) was 76.86±42.6 nmol/L. As much as 35.19% were vitamin D insufficient and 16.66% deficient. These groups were definied based on 25OH D concentration between 37.5 and 75L or <37.5 nmol/L. There was a weak but significant correlation between vitaminD concentration and the age of patients (p=0.026, r=-0.303, Spearman correlation), but no correlation was found with other laboratory parameters. Chi2 test revealed association between vitamin D level groups and the presence of RF (p=0.047) as well as autoimmune thyreoiditis (p=0.009).
Conclusions Reduced vitamin D level might contribute to the pathogenesis of primary Sjogren’s disease, but until now only a few data are available. Further prospective studies are required in larger cohort of patients in comparison with other autoimmune diseases and healthy population.
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Disclosure of Interest None Declared
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