Background Although immune-mediated rheumatic disorders, particularly systemic lupus (SLE), are commonly associated with increased cardio-vascular risk (CVR), there are still controversies about the advantage of traditional scores such as SCORE and Framingham for CVR stratification in such patient population.
Objectives To identify the ideal score for the stratification of CVR in patients with SLE.
Methods Prospective observational study on 72 consecutive SLE patients (1987 ACR diagnostic criteria) (68 women, mean age of 48±13.8 years) who were evaluated based on a predefined protocol including disease activity and damage parameters (SELENA-SLEDAI, BILAG), traditional (diabetes mellitus, obesity, arterial hypertension, smoking, dyslipidemia) and non-traditional cardio-vascular risk factors (hsCRP and homocysteine level), and classic CVR scores (Framingham, SCORE). Statistics was done in SPSS-17, p<0.05%, patients being analyzed according to the presence of ischemic cardio-vascular events (stable angina, coronary artery disease).
Results Although more than half (51.4%) of cases had no CVR (Framingham, SCORE), we have demonstrated increased CVR in patients with preexistent cardio-vascular events (21%), SCORE risk featuring a higher prediction level than Framingham. On the other hand, both hsCRP and homocysteine levels highly correlated with CVR scores, displaying predictive role for coronary artery disease, mainly in active disease subset.
Conclusions A novel algorithm for the evaluation and CVR stratification in patients, considering both classic and inflammatory parameters, is mandatory.
Disclosure of Interest None Declared