Objectives Metabolic syndrome (MS) is a multidisciplinary case including classic cardiovascular risk factors especially hypertension, obesity, glycosine tolerance and dyslipidemia. There are contradictory results in the literature about the frequency of MS in patients with Rheumatoid arthritis (RA). The purpose of this study is to study MS frequency and insulin resistance in patients with RA and also to examine the inflammation indicators of MS, disease activity, disease duration as well as the relationship with the medications taken.
Methods The study included 100 female patients diagnosed with RA according to the diagnosis criteria of American Rheumatism Association that applied to Physical Medicine and Rehabilitation Department of the Faculty of Medicine of Akdeniz University. The control group was formed by 100 female cases without any inflammatory rheumatism disease at similar ages that applied to the same policlinic. All cases within the scope of the study were applied detailed systemic and muscle-skeleton system examination and their fasting blood glucose, triglyceride, HDL cholesterol, insulin, uric acid, fibrinogen, Hs-CRP and erythrocyte sedimentation rate (ESH) were monitored. Disease starting age and duration, medications taken and disease activity (evaluated with DAS-28) of RA patients were recorded. In all cases, MS presence was studied according to NCEP ATP III and IDF 2005 diagnosis criteria and also insulin resistance was studied by HOMA-IR method.
Results When RA patients and control group was evaluated in respect to MS presence, it was detected that there was MS in 27% of RA patients and 28% of control group according to NCEP ATP III criteria and in 33% of RA patients and 44% of control group according to IDF 2005 criteria. In both methods, there was nostatistically significant difference between RA and control groups in respect of MS frequency. In respect of insulin resistance that was calculated by HOMA-IR, there was no statistically significant difference between RA patients and control group. When RA patients were evaluated by means of certain clinical and laboratory parameters within itself, it was found that ESH, serum uric acid and insulin levels in RA patients as well as the disease activity that was evaluated with DAS-28 and also HOMA-IR values were statistically higher than the ones without MS. Also MTX-treated patients was determined significantly lower in the presence of MS.
Conclusions In conclusion, it was determined in this study that MS frequency in RA patients was similar to control group. In addition, it was found that serum uric acid and ESH levels and also disease activity was high in RA patients with MS. Consequently, controlling of inflammation and disease activity in RA patients can reduce MS frequency.
Disclosure of Interest None Declared