Background Women with chronic inflammatory diseases increasingly solicit assisted reproductive techniques (ART) due to infertility, but there is little information about success rates of these techniques in such patients.

Objectives To analyze pregnancy rates after artificial insemination (AI) and in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) in patients with inflammatory rheumatic disease.

Methods Patients: 17 women with inflammatory rheumatic disease: 6 rheumatoid arthritis, 2 spondyloarthritis, 8 systemic lupus erythematosus and 1 Behcet disease, monitored by our department.Mean age 33 years (range 24-40) and 6±2 years from diagnosis of disease, currently inactive or with low clinical activity.Due to infertility, these patients underwent ART: 7 with AI and 9 with IVF-ICSI.

Method: We analyzed success rates of both techniques according to patient age, one of the factors that most influence outcome.

Results Pregnancy rate per cycle of AI was 12% with a cumulative rate of 32% after four cycles.In patients over 35 years the pregnancy rate per cycle was reduced to 6%.

The pregnancy rate per attempt using IVF-ICSI was 21% with a cumulative rate of 34% after three attempts. In women over 35 years the success rate was 19%.

Conclusions The pregnancy rates of both AI and IVF-ICSI were lower in this series of patients with inflammatory rheumatic disease than those reported for the general population.

Disclosure of Interest None Declared