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AB0373 Interrelation of level pro-hepcidin with development of an anemia in patients with rheumatoid arthritis
  1. D. Belenkiy,
  2. E. Galushko,
  3. A.A. Novicov
  1. Niir RAMS, Institute of Rheumatology, Moscow, Russian Federation

Abstract

Background The leading pathogenetic factor in development of the anemia of chronic disease is disturbance of the exchange of iron. Pro-hepcidin, a recently indentified peptide, acts as a central regulating the uptake of dietary iron and its mobilization from macrophages and hepatic stores. It is considered as a mediator of anemia of inflammation.

Objectives to estimate interrelation of level Pro-hepcidin with indicators of activity of inflammatory process and hemoglobin level (Hb) at patients with (RA).

Methods It has been included 76 patients with RA average- 46,3 years, duration of desease 60[17;96] month, activity on DAS 28- 6,15±1,35. The anemia has been diagnosed for 47 patients by criteria the CART (Hb 104,3±21,4 g/l. Concentration of serum pro-hepcidin in blood defined an immunoenzymatic method.Serum iron defined with the help a method with use of an ascorbate and ferrosin as a reagent, Serum firms Roche Integra Gen.2 Ferritin defined with the help immunology, a method based on agglutination of a ferritin with latex particles, the covered antibodies to a ferritin.

Results It has been included 76 patients with RA (65 women and 11 men), compare age - 46,3 years, duration of disease 60 [17; 96] month, activity on DAS28 –(6,15±1,35 points).The anemia has been diagnosed for 47 patients by criteria the CART (Hb 104,3±21,4 g/l).Patients with anemia (N=47) and with out (N=29) were comparable (p>0,05) on age 45,5±14,3 and 48,9±14,3 years, duration of illness 60 [36; 96] and 60 [17; 84] month, DAS28-6,4±1,7 and 5,9±1,0 levels of CRP (44,5[20,3; 110,2] and 37,8[12,7; 47,2] mg/l) ESR (46,5±21,3 and 41,0±20,3 mm/h). Serumal iron was much more low at patients with the anemia (9,5±5,6 and 18,5±7,7 mkmol/l, p=0,01).The Pro-hepcidin level was higher at patients with RA and with the anemia, than with out it (120,3±56,1comparison with 90,3±37,9ng/ml, p=0,04).In group with the anemia direct correlation between hemoglobin level, Pro-hepcidin and (r=0,45; p=0,01) in the ferritin (r=0,52; p=0,002). Has been taped Pro-hepcidin also correlated with serumal iron, levels DAS28.

In group of patients with normal concentration of hemoglobin Pro-hepcidin positively correlated with indicators of activity of inflammatory process CRP, ESR DAS28 (rCPR=0,51, p=0,03; rESR=0,62, p=0,01; rDAS28=0,4; p=0,025) interrelations levels of hemoglobin and serum iron were not.

Conclusions At patients with Rheumatoid arthritis (RA) rising of level serum Pro-hepcidin in blood is bound not only to activity of inflammatory process, but also is independent predictor of developments ACD.

Disclosure of Interest None Declared

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