Background Previous echocardiographic studies have reported higher prevalence of diastolic dysfunction in patients with rheumatoid arthritis (RA) (1-4). A few of them have found a correlation between disease duration and diastolic dysfunction (5,6). There are less data regarding the influence of disease activity, specific serologic markers and body proportions on diastolic dysfunction in RA (3,4).
Objectives The aim of the study was to assess: (a) the possible impact of specific serologic markers on diastolic dysfunction; (b) the possible effects of disease activity scores on diastolic dysfunction; (c) the possible effects of the body proportions on diastolic dysfunction.
Methods The study included 80 RA patients (70 females, 10 males) with no clinically evident CV disease or obesity and 80 matched healthy controls. Upon clinical and laboratory evaluation, all subjects underwent complete echocardiographic examination.
Results Isovolumetric relaxation time (IVRT) prolongation as the first sign of diastolic dysfunction was present in 36.25% of RA patients and in 15% of controls (P=0.002). IVRT was found to correlate with anti-CCP antibodies (r=0.382; p=0.001), DAS28-CRP (r=0.204; p=0.039) and waist-to-hip ratio (r=0.266; P=0.018). The ratio of early and late transmitral wave (E/A ratio) was found to correlate with body mass index (BMI) (r=-0.376; P=0.001) and age (r=-0.524; P<0.001).In multivariate linear regression analysis anti-CCP titer demonstrated significant correlation with IVRT while E/A ratio independently correlated with age and DAS28-CRP.
Conclusions Anti-CCP antibodies, DAS28-CRP and central obesity are predictors of cardiac involvement in the RA.
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Disclosure of Interest None Declared
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