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AB0265 RADAI-5 remission represents 2011 ACR/EULAR proposal for remission with high specificity
  1. B. Rintelen1,2,
  2. J. Sautner1,2,
  3. P.M. Haindl1,
  4. H.T. Mai1,
  5. H.-P. Brezinschek3,
  6. B.F. Leeb1,2
  1. 12Nd Departement For Internal Medicine, Lower Austrian Center For Rheumatology, Lower Austrian State Hospital Weinviertel Stockerau
  2. 2Karl Landsteiner Institute for Clinical Rheumatology, Stockerau
  3. 3Department of Internal Medicine, Division of Rheumatology and Immunology, Medical University Graz, Graz, Austria

Abstract

Background New remission criteria for Rheumatoid Arthritis (RA) were recently proposed by ACR and EULAR (1). It was of interest if a patient centred disease activity score as the Rheumatoid Arthritis Disease Activity Index based on 5 questions (RADAI-5) (2,3) meets these criteria.

Objectives To approve RADAI-5 remission criteria with the recently proposed ACR/EULAR remission criteria for rheumatoid arthritis.

Methods 729 RA outpatients were assessed according to the RADAI-5 as well as the two approaches of the recently published ACR/EULAR proposal (Boolean based and index based) being in remission or not. 1844 assessments (mean interval of the single assessments 6.7 months, mean number of assessments/pat 2.5) were included in this study. Sensitivity, specificity, positive and negative likelihood ratio (+LR, -LR) and ROC-analysis (area under the curve (AUC)) were performed to illustrate the relation of the 3 different approaches defining remission.

Results Comparing the RADAI-5 remission group with Boolean based definition showed a sensitivity of 83%, specificity of 88%, +LR 6.7, -LR 0.19 and AUC 0.85: Comparison with index based definition showed 59%, 91%, 5.96, 0.46, 0.75 respectively. Core set parameters were significantly different comparing assessments of the RADAI-5 and Boolean- as well as index based remission group except patient’s global assessment compared with the index based and ESR with the Boolean based definition group.

Conclusions Although core set parameters are different, the RADAI-5 remission is comparable to ACR/EULAR remission criteria showing high specificity with the index based as well as Boolean based definition on group level.

  1. Felson DT, Smolen JS, Wells G et al. Ann Rheum Dis. 2011 Mar;70(3):404-13;

  2. Leeb BF, Haindl PM, Maktari A et al. J Rheumatol. 2008 Jul;35(7):1294-9;

  3. Rintelen B, Haindl PM, Sautner J et al. J Rheumatol. 2009 May;36(5):918-24

Disclosure of Interest None Declared

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