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AB0230 Anorectal involvement in very early systemic sclerosis (SSC)
  1. G. Lepri1,
  2. S. Bellando Randone1,
  3. S. Guiducci1,
  4. I. Giani2,
  5. G. Carnesecchi1,
  6. C. Bruni1,
  7. J. Blagojevic1,
  8. A. Radicati1,
  9. F. Pucciani3,
  10. M. Matucci Cerinic1
  1. 1Department of Medicine, Division of Rheumatology, University of Florence, Florence
  2. 2Chirurgia Generale, USL8 Toscana, Arezzo
  3. 3Chirurgia Generale di Urgenza 2, University of Florence, Florence, Italy

Abstract

Background In SSc anorectal dysfunction is reported in 50-70% with a high impact on patients’ quality of life.

Objectives Evaluation of anorectal involvement and its correlation with esophageal involvement in very early SSc.

Methods 56 patients (55 female), mean age 49,2±14 years, with very early SSc were evaluated with anorectal and esophageal manometry. The demographic data, anorectal symptoms (fecal incontinence and constipation), Raynaud phenomenon (presence/absence, duration), autoantibodies profile (anticentromere antibodies [ACA], antinuclear antibodies [ANA], anti-Scl70 antibodies [Scl70]), videocapillaroscopy patterns (Normal, Early, Active, Late), puffy fingers, digital ulcers were recorded for all patients.

Results Anorectal manometry was abnormal in 85% of patients, in these patients an esophageal involvement was found (absence of esophageal peristalsis in 29% of patients and abnormal peristalsis in 67,7% of patients). Anorectal symptoms were found in 5 patients (12,5%). In 16 patients anorectal manometry was not performed because of scarce tolerance of the procedure.

Conclusions Anorectal disorders are frequently detected in very early SSc even in asymptomatic patients. Our data demostrate that very early SSc is charaterized by contemporary esophageal and anorectal involvement.

Disclosure of Interest None Declared

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