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AB0144 The expression of NKG2D ligands in synovial cell of rhuematoid arhtirits
  1. S.Y. Lee1,
  2. W.T. Chung1,
  3. S.W. Lee1,
  4. J.-H. Bae2,
  5. C.W. Lee3,
  6. E.J. Kang4
  1. 1Rheumatology of Internal Medicine, Dong-A University Hospital
  2. 2Biochemistry, Pusan national univiersity
  3. 3Rheumatology of Internal Medicine, Bapist hospital
  4. 4Rheumatology of Internal Medicine, Pusan medicla hospital, Pusan, Korea, Republic Of

Abstract

Background NK cellare approximately 10–15% of circulating lymphocytes and 5% of lymphocytes in lymphoid tissue and a subset of NK cells has been detected in the synovial fluid (SF) from rheumatoid arthritis (RA) patients recently. The best characterised NK cell activating receptor is NKG2D, is expressed on all human NK cells and the ligands for NKG2D are not expressed on normal, healthy tissue, but are in induced under conditions of cellular stress such as inflammation and malignant transformation

Objectives To investigated expression of NKG2D ligands in synovial cell of rhuematoid arhtirits

Methods Synovial cell was cultured from SF of RA patients. The subculture was conducted for 5-6 passages and the PCR was done for detection of NKG2D ligands. To evaluated NKG2D ligands in inflammatory RA synoviocytes, TNF-α were treated

Results Five NKG2D ligands (MICA, MICB, ULPB1, ULBP2, ULBP3) were expressed in both RA synoviocytes and inflammatory RA synoviocytes

Conclusions RA synoviocytes had NKG2D ligands, so NKG2D receptors in NK cell were associated with pathogenesis of RA. The blocking of NKG2D ligands was the one of method in RA treatment

  1. Emerging role for NK cells in the pathogenesis of inflammatory arthropathies, Paola Conigliaro, Rossana Scrivo, Guido Valesini, Roberto Perricone. Autoimmunity Reviews 10 (2011) 577–581

Disclosure of Interest None Declared

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