Background Rheumatoid arthritis (RA) is a complex polygenic autoimmune inflammatory disease with high risk of cardiovascular (CV) complications as consequence of accelerated atherosclerosis . Recent studies have emphasized the relevance of several genetic polymorphisms in the susceptibility to CV disease in RA [2, 3]. Genome-wide association studies (GWAS) revealed that the polymorphism rs599839 (A>G) is associated with CAD and with higher plasma total and LDL cholesterol levels .
Objectives Wwe aimed to determine, for first time, the potential role of rs599839 polymorphism in the development of endothelial dysfunction in a cohort of RA patients without clinically evident CV disease.
Methods 128 RA patients without history of CV events were genotyped for rs599839 A/G polymorphism. Presence of endothelial dysfunction was assessed by brachial ultrasonography (brachial flow-mediated endothelium-dependent [FMD]).
Results Patients carrying the allele G exhibited more severe endothelial dysfunction (FMD%: 4.61±3.94%) than those carrying the wild allele A (FMD%: 6.01±5.15%) (p=0.08). Adjustment for gender, age at the time of study, follow-up time and classic CV risk factors disclosed a significant association between the rs599839 polymorphism and FMD (G vs. A: p=0.0062).
Conclusions Our results confirm an association of the rs599839 polymorphism with endothelial dysfunction in RA.
This study was supported by two grants from “Fondo de Investigaciones Sanitarias” PI06-0024 and PI09/007/48 (Spain) and partially supported by RETICS Program, RD08/0075 (RIER) from ``Instituto de Salud Carlos III'' (ISCIII).
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Disclosure of Interest None Declared
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