Background Genetic factors may play a role in the development of systemic lupus erythematous (SLE), and endothelial nitric oxide synthase (eNOS) polymorphisms have been associated with SLE.
Objectives The aim of this study was to determine whether eNOS polymorphisms confer susceptibility to SLE and lupus nephritis (LN).
Methods A meta-analysis was conducted on the associations between the 4b/a, G894T, and C786T polymorphisms of eNOS and SLE and LN using; 1) the allele contrast, 2) the recessive, 3) the dominant, and 4) the additive models.
Results A total of 8 studies, which included 1297 cases and 1214 controls, were included in the meta-analysis. Meta-analysis showed no association between SLE and the 4b/a polymorphism in all study subjects. Stratification by presence of LN indicated a significant association between the a allele and the aa+ab genotype of the 4b/a polymorphism and LN in SLE patients (OR =2.125, 95% CI =1.289–3.054, p=0.003; OR =2.655, 95% CI =1.509–4.671, p=0.001). No association was found between SLE and the G894T polymorphism using the allelic, recessive, or dominant, or additive models. Meta-analysis of the T786C polymorphism showed a tendency of an association between the TT genotype and SLE (OR =1.220, 95% CI =1.000–1.489, p=0.050), and meta-analysis of the TT vs. CC genotype of the C786T polymorphism in group in H-W equilibrium revealed a significant association between the TT genotype and SLE (OR =1.643, 95% CI =1.021–2.644, p=0.041).
Conclusions This meta-analysis of published studies shows that the 4b/a polymorphism may be associated with the development of LN, and the C786T polymorphism may be associated with SLE susceptibility.
Disclosure of Interest None Declared
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