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AB0004 HLA association of behçet’s disease in HLA-B*51negative german and turkish patients
  1. A. Kuranov1,
  2. F. Riewerts2,
  3. I. Kötter2,
  4. J. Gamper-Tsigaras1,
  5. I. Steiert1,
  6. C.A. Müller1
  1. 1Section for Transplantation Immunology and Immunohematology, Center for Medical Research, University Hospital
  2. 2Department II of Internal Medicine, University Hospital, Tübingen, Germany

Abstract

Objectives Behçet’s disease (BD) as systemic vasculitis of unknown etiology is associated with HLA-B*51 in different European and Asian populations. HLA-A*26 was claimed as additional BD susceptibility marker in Japanese and Greek patients independent of HLA-B*51. This study was performed to test for HLA-A associations in German and Turkish BD populations. HLA-B*51 negative BD patients were compared with respective control populations.

Methods 62 German and 44 Turkish patients lacking HLA-B*51 were analyzed in comparison to healthy German (N=1500) and Turks (N=77) negative for B*51. HLA-A/B genotypes were determined by SSOP (Luminex Corp.) Fisher’s exact test and Odds ratio (OR) were used for statistical evaluation.

Results HLA-A*26 was significantly more frequent in German patients (14.52% patients vs. 5.9% healthy Germans, chi-square =6,07, OR =2,69, p<0.0137). When individuals carrying a second Bw4+ HLA-B locus allele were excluded from this analysis, HLA-A*26 association with BD was no longer observed. Frequency of HLA-Bw4+ (HLA-A and B alleles) alleles, however, was significantly different in German B*51 negative BD patients versus controls (patients vs. controls: 72.6% vs. 54.5%, chi-square =7,18, OR =2,21, p<0.0058).In addition a significant decrease in the frequency of HLA-A*03 was observed in German BD patients (patients vs. controls: 14.5% vs. 30.1%, chi-square =6,20, OR =0,39, p<0.0127).No significant association of any of the tested HLA-A alleles nor of the HLA-Bw4 determinant in B*51 negative Turkish patients was seen.

Conclusions Although B*51 negative German BD patients showed an association with HLA-A*26 as in Japanese and Greek, this appeared to reflect a higher frequency of Bw4+alleles inherited in linkage. Thus, stronger association with HLA-Bw4 in the B*51 negative Germans may indicate relevance in BD pathogenesis. A protective factor may be inherited in association with HLA-A*03 in Germans. No BD association to HLA-A alleles was detected in Turks, possibly due to the low numbers of patients analyzed.

Disclosure of Interest A. Kuranov Grant/Research support from: DAAD, F. Riewerts: None Declared, I. Kötter: None Declared, J. Gamper-Tsigaras: None Declared, I. Steiert: None Declared, C. Müller: None Declared

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