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SAT0426 Prevalence of joint hypermobility and hypermobility syndrome in 100 IRAQI patients with asthma
  1. F.I. Gorial1,
  2. Z.S. Al-rawi1,
  3. A.D. Mohammad2
  1. 1Medicine-Rheumatology unit, college of medicine, Baghdad
  2. 2Medicine, Baghdad Teaching Hospital, Baghdad, Iraq

Abstract

Background Benign joint hypermobility syndrome (BJHS) is a hereditable disorder of connective tissue (1). Asthma may be caused by a connective tissue defect (2). Changes in the mechanical properties of the bronchial airways and lung parenchyma may underlie the increased tendency of the airways to collapse (3,4)

Objectives To assess joint hypermobility (JHM) and hypermobility syndrome (HMS) in Iraqi patients with asthma & to evaluate the predictors of this relationship if present.

Methods A sample of 100 Iraqi patients with asthma, and another 100 healthy individuals matched for age and sex, serving as control group were studied. Full history was taken and complete clinical examination was done for all individuals in both groups. Bieghton score and Brighton Criteria were performed on patients & controls.

Results Both JHM and HMS were significantly more in patients with asthma than control group [68 (70.1%) versus 29 (29.9%) (p=0.000, OR (95% CI=2.26 (1.65-3.09))]. JHM (only) was observed in 16 (59.3%) asthmatic patients while it was 11 (40.7%) in controls (p=0.007, OR (95% CI)=3.23 (1.35-7.73)). Also HMS was observed in 52 (74.3%) asthmatic patients while it was 18 (25.7%) in controls (p=0.000, OR (95%CI)=6.41 (3.25-12.64)).

Mean age, female sex, Family history (FH) of JHM, low body mass index (BMI), and low waist circumference were significant predictors for increased JHM in patients with asthma. The majority of asthmatics on steroids have HMS.

Conclusions There is increased frequency of JHM and HMS (70.1%) in Iraqi patients with asthma compared to healthy controls. Mean age, female sex, FH of JHM, low BMI, and low waist circumference are significant predictors for JHM and HMS among asthmatic patients

  1. Malfait F, Hakin AJ, De Paepe A, Grahame R. The genetic basis of the joint hypermobility syndromes. Rheumatology (Oxford) 2006;45:502–7.

  2. Morgan A W, Pearson S B, Davies S, et al. Asthma and airways collapse in two heritable disorders of connective tissue. Ann Rheum Dis 2007;66:1369–1373. doi: 10.1136/ard.2006.062224

  3. Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006;7:95–100.

  4. Zweers MC, Bristow J, Steijlen PM, et al. Haploinsufficiency of TNXB is associated with hypermobility type of Ehlers– Danlos Syndrome. Am J Hum Genet 2003; 73:214–7.

Disclosure of Interest None Declared

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