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SAT0382 Combination of quantitative ultrasound and frax® in evaluation of structural-functional state of bone in postmenopausal women
  1. V. Povoroznyuk,
  2. N. Grygorieva,
  3. V. Povorozniuk
  1. Institute of Gerontology Ams Ukraine, Kyiv, Ukraine

Abstract

Background The aim of the study was to estimate the informative value of quantitative ultrasound and its combination with FRAX® in evaluation of structural-functional state of bone in Ukrainaian postmenopausal women.

Objectives 363 postmenopausal women aged 45-87 years were examined, average age 65,1±0.5 years, duration of postmenopausal period 16,5±0.5 years.

Methods Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometer (DXA) “Prodigy” and calcaneus quantitative ultrasound (QUS) “Sahara”. The ten years probability of major osteoporotic fracture calculated with FRAX® tool.

Results There is difference in distribution of bone indexes in depending of used methods. Among women which had osteoporosis of femoral neck by DXA, 34% had osteoporosis, 57% - osteopenia, 9% - norma data by QUS. Sensitivity of QUS indexes ranging was from low to moderate, but specificity was low (with femoral neck – 38% and 39%, total hip – 63% and 34%, lumbar spine – 45% and 34%, total body – 56% and 34% accordingly). Such sensitivity and specificity increased when combining QUS with the ten years probability of major osteoporotic fracture without BMD (FRAX®) (with femoral neck – 71% and 87%, total hip – 90% and 100%, lumbar spine – 72% and 83%, total body – 79% and 91% accordingly).

Conclusions QUS of is informative method in evaluation of structural-functional state of bone in postmenopausal women. Sensitivity and specificity increased when combining QUS with FRAX® from 38% and 34% up to 90% and 100% accordingly.

Disclosure of Interest None Declared

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