Background The aim of the study was to estimate the informative value of quantitative ultrasound and its combination with FRAX® in evaluation of structural-functional state of bone in Ukrainaian postmenopausal women.
Objectives 363 postmenopausal women aged 45-87 years were examined, average age 65,1±0.5 years, duration of postmenopausal period 16,5±0.5 years.
Methods Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometer (DXA) “Prodigy” and calcaneus quantitative ultrasound (QUS) “Sahara”. The ten years probability of major osteoporotic fracture calculated with FRAX® tool.
Results There is difference in distribution of bone indexes in depending of used methods. Among women which had osteoporosis of femoral neck by DXA, 34% had osteoporosis, 57% - osteopenia, 9% - norma data by QUS. Sensitivity of QUS indexes ranging was from low to moderate, but specificity was low (with femoral neck – 38% and 39%, total hip – 63% and 34%, lumbar spine – 45% and 34%, total body – 56% and 34% accordingly). Such sensitivity and specificity increased when combining QUS with the ten years probability of major osteoporotic fracture without BMD (FRAX®) (with femoral neck – 71% and 87%, total hip – 90% and 100%, lumbar spine – 72% and 83%, total body – 79% and 91% accordingly).
Conclusions QUS of is informative method in evaluation of structural-functional state of bone in postmenopausal women. Sensitivity and specificity increased when combining QUS with FRAX® from 38% and 34% up to 90% and 100% accordingly.
Disclosure of Interest None Declared