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SAT0313 The link between enthesitis and arthritis in psoriatic arthritis: A switch to a vascular phenotype at insertions may play a role in arthritis development
  1. S.Z. Aydin1,
  2. Z.R. Ash2,
  3. I. Tinazzi3,
  4. C. Castillo-Gallego4,
  5. C. Kwok5,
  6. C. Wilson5,
  7. M. Goodfield6,
  8. P. Gisondi7,
  9. A.L. Tan2,
  10. H. Marzo-Ortega2,
  11. P. Emery2,
  12. R. Wakefield2,
  13. D. McGonagle2
  1. 1Rheumatology, Medeniyet Univ Goztepe Training&Research Hosp, Istanbul, Turkey
  2. 2Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals, Leeds, United Kingdom
  3. 3Unit of Rheumatology, University of Verona, Verona, Italy
  4. 4Unit of Rheumatology, hospital Universitario La Paz, Madrid, Spain
  5. 5Dermatology
  6. 6Leeds Teaching Hospitals, Leeds, United Kingdom
  7. 7Department of Medicine, Section of Dermatology and Venereology. University of Verona, Verona, Italy

Abstract

Background Subclinical enthesopathy is recognised in both psoriasis and psoriatic arthritis (PsA). However, there is limited work directly comparing power Doppler (PD) changes at the insertions between patients with PsA and psoriasis.

Objectives This study used ultrasonography (US) with PD to test the hypothesis that subclinical enthesopathy in PsA was associated with an “inflammatory” or vascular phenotype compared to that seen in psoriasis.

Methods 100 patients with a mean (SD) age of 46 (15) (42 with psoriasis and 58 with PsA) and 23 matched healthy controls (HC) from two centres were included. A total of 1230 lower limb entheses were scanned by ultrasonographers blinded to clinical details. Both inflammatory and chronic features of enthesopathy were scored.

Results Psoriasis patients (with or without arthritis) had higher inflammation related enthesopathy scores than HC (for inflammation p<0.0001, for chronicity p=0.02, for total US scores p<0.0001). The PsA patients had higher US enthesopathy scores than psoriasis patients (inflammation p=0.04, chronicity p=0.02) and HC (inflammation p<0.0001, chronicity p=0.003). When symptomatic entheses were excluded, PsA patients still had higher PD scores than psoriasis patients (p=0.003). Doppler positivity in at least one entheseal site was observed more frequently in PsA (21/58, 36.2%) than psoriasis (4/42, 9.5%; p=0.002). The tender joint count (r2 =0.21; p=0.03) and swollen joint count (r2 =0.29; p=0.003) correlated to US scores at distant sites of subclinical enthesopathy.

Conclusions This study shows that the US appearances of subclinical enthesitis in psoriasis differ from the subclinical enthesitis in PsA, with PsA patients having more power Doppler. This is suggestive of a more inflammatory or vascular process in PsA, and offers potentially novel insights into the progression from skin to joint disease in psoriasis.

Disclosure of Interest None Declared

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