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SAT0312 Psoriasis and psoriatic arthritis among natives and mestizos from the andean mountains region of peru
  1. S.M.A. Toloza1,
  2. O. Vega-Hinojosa2,
  3. V. Chandran3,
  4. R. Valle-Oñate4,
  5. L.R. Espinoza5
  1. 1Medicine, Hospital San Juan Bautista, Catamarca, Argentina
  2. 2Medicine, Hospital III, Juliaca, Peru
  3. 3Medicine, University of Toronto, Toronto, Canada
  4. 4Medicine, Universidad de La Sabana, Bogotá, Colombia
  5. 5Medicine, Louisiana State University, New Orleans, United States

Abstract

Background Previous epidemiological studies described that both Psoriasis (Ps) and Psoriatic Arthritis (PsA) are diseases with negligible prevalence among Natives from the Andean mountains of Peru. We herein first report the presence of Ps and PsA as well as the clinical status of Peruvian Natives and Mestizos with psoriatic disease.

Objectives Our purpose was to describe the most salient demographic and clinical features of Peruvian Natives and Mestizos with Ps and PsA from Juliaca, Puno in the Andean mountains region of Peru.

Methods During October 1st 2008 to December 31st 2010 consecutive patients attending the rheumatology clinic at the Hospital III in Juliaca, Puno (Southern Peru) at 3824 meters above sea level were carefully assessed for the presence of PsA satisfying the CASPAR classification criteria. The diagnosis of Ps was confirmed by a dermatologist. Descriptive statistics were used to describe the study population.

Results Twelve patients with a mean (SD) age of 49.3 (10.7) years fullfilling CASPAR classification criteria were identified. There were 7 (58%) men and 5 (42%) women. 7 PsA patients were Natives of Quechua Ancestry and 5 Mestizos of European and Quechua mix. The main demographic and clinical features of the two ethnic groups included are summarized in table. At the time of first clinical visit all Natives with PsA had no family history of both Ps and PsA and exhibited an established disease (ranging from 12-72 months), were more likely to have a polyarticular disease, and a more severe disease phenotype evidenced by the presence of radiographic damage than Mestizos with PsA. Methotrexate exposure (dose ranging from 15-20 mg/wk) was almost universal in both Natives and Mestizos as was the absence of exposure to biological agents in spite of radiographic damage.

Conclusions We first report Ps and PsA in the absence of a family history among Natives of the Andean Mountains of Peru in whom the CASPAR criteria was successfully applied to classify PsA patients. At the time of first visit PsA among the indigenous appeared to be chronic and more severe as most of these patients had radiographic damage.

Disclosure of Interest None Declared

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