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SAT0266 Undifferentiated spondyloarthritis characterization of a group of colombian patients
  1. D.P. Pena1,
  2. J. Londono2,
  3. A.M. Santos3,
  4. W. Bautista1,
  5. C. Romero-Sánchez1,
  6. A. Cortés1,
  7. R. Valle-Oñate1,2
  8. on behalf of Grupo Espondiloatropatías Hospital Militar Central/Universidad de La Sabana
  1. 1Rheumatology, Hospital Militar Central, Bogota
  2. 2Rheumatology, Universidad de La Sabana, Chia
  3. 3Biologia, Universidad de los Andes, Bogota, Colombia

Abstract

Background Undifferentiated spondyloarthritis are part of the spondylitis group and share clinical features with other subtypes. In our environment has been reported that these undifferentiated forms of the disease are the most frequent group, contrary to what happens in the Caucasian population possibly by environmental influences, genetic and ethnic differences

Objectives To describe demographic, clinical findings and laboratory in a group of Colombian patients with undifferentiated spondyloarthritis

Methods We selected 162 patients with undifferentiated spondyloarthritis that did not meet criteria for other spondyloarthritis according to ESSG, who attended the Rheumatology clinic of the Central Military Hospital, Bogotá 2001-2011. The clinical, demographic characteristics and HLA typing were collected as recommended by ASAS. 121 patients underwent HLA typing (PCR-SSP). The data analysis was performed from a statistical package SPSS

Results We identified 162 patients, 102 (63%) were male, 60 (37%) women. The average age was 35±11.4 years, age at onset 29±9.3 and the evolution time of the disease was 6.1±7.7 years.The patients had a history of enthesopathy 117 (72%), arthritis 102 (63%), inflammatory back pain 82 (51%), buttock pain 56 (34,5%), dactylitis 21 (13%), infection 13 (8%), family history 13 (8%) and uveitis 10 (6,1%). The pattern of initial presentation was back pain 66 (41%), arthritis 40 (25%), several symptoms 38 (23,4%), enthesopathy 13 (8%), buttock pain 4 (2,4%) and uveitis 1 (0,6%). The clinical findings at the time of diagnosis: Enthesopathy 105 (65%), sacroilitis 66 (41%), arthritis 30 (19%) and dactylitis 6 (4%). The ASAS criteria: Peripheral 105 (65%) and Axial 57 (35%). Of the 121 patients with HLA typing, 31 (25,6%) were B27, 24 (19,8%) B15 and 66 (54,5%) other alleles B. Other data: Schober: 4.2±1.2, BASFI: 5.3±2.2, BASDAI: 5.9±2.1, ESR: 16.6±13.9, CRP: 0.7±2.2

Conclusions The group of undifferentiated spondyloarthritis patients analyzed, are characterized by the presence of several signs and symptoms within which the most frequent were enthesitis, peripheral arthritis and back pain, similar to what it is described in other series. Most of this group of patients met ASAS peripherals criteria. The HLA-B27 was found with low frequency being most prevalent other B alleles contrary to what has been described in Caucasians, which may influence the development of the disease. The above leads to a further long-term follow up and determine in this group: how many patients get recovered, which of these patients evolve into an ankylosing spondylitis and what are other factors influencing this evolution in our population

  1. Zeidler H, Mau W, Khan MA. Undifferentiated spondyloartrhopathies. Rheum Dis Clin North Am 1992;18:187-202

  2. Valle-Oñate R, Candia L, Romero-Sánchez C, Iglesias-Gamarra A, Caballero-Uribe C, Santos-Moreno P, Reyes E, Londono J. Epidemiology of Spondyloarthritis in Colombia. Am J Med Sci 2011;341(4):293–294

Disclosure of Interest None Declared

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