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SAT0098 Seropositivity of anti-cyclic citrullinated peptide antibody is more prevalent in unaffected first-degree relatives with multicases families of rheumatoid arthritis
  1. W.-T. Chung1,
  2. H. Lee2,
  3. J.H. Kim2,
  4. S.-H. Park2,
  5. J.-Y. Choe2,
  6. S.-K. Kim2
  1. 1Dong-A University College of Medicine, Busan
  2. 2Catholic University of Daegu School of Medicine, Daegu, Korea, Republic Of

Abstract

Objectives This study elucidates the prevalence of seropositivity and determinants for rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), and anti-mutated citrullinated vimentin (anti-MCV) antibodies in unaffected first-degree relatives (FDRs) of rheumatoid arthritis (RA) patients.

Methods The subjects (135 with RA and 202 of their FDR) were enrolled in this case-control study. Serum RF, anti-CCP antibody, and anti-MCV antibody were measured. Subjects with multi-case families (two or more affected FDRs within the study family) were identified. Multivariate logistic regression analysis was used to determine the risk factors associated with RA-related autoantibodies.

Results Seropositivity for RF, anti-CCP antibody, and anti-MCV antibody in unaffected FDRs was 14.4%, 5.0%, and 13.4%, respectively. Anti-CCP antibody was more prevalent in FDRs with multi-case families (17.8%) than in those without multi-case families (1.3%) (p<0.0001). Significant correlations were detected between RA-associated autoantibodies in the FDR group (r =0.366, p<0.0001 between RF and anti-CCP antibody; r =0.343, p<0.0001 between RF and anti-MCV antibody; r =0.849, p<0.0001 between anti-CCP antibody and anti-MCV antibody). The anti-CCP antibody seropositivity in FDRs was significantly associated with the presence of multi-case families within FDRs (odds ratio: 49.8, 95% confidence interval: 5.6 – 441.6 after adjustment for age and gender).

Conclusions The association between anti-CCP antibody seropositivity and having a multi-case family in the unaffected FDR group suggests that genetic and/or environmental factors may increase the unaffected FDR subjects’ risk of developing RA.

Disclosure of Interest None Declared

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