Article Text

FRI0407 Accumulation of metabolic risk factors raises the risk of occurrence and progression of knee osteoarthritis: The road study
  1. N. Yoshimura1,
  2. S. Muraki2,
  3. H. Oka1,
  4. S. Tanaka3,
  5. H. Kawaguchi3,
  6. K. Nakamura4,
  7. T. Akune2
  1. 1Department of Joint Disease Research
  2. 2Department of Clinical Motor System Medicine
  3. 3Department of Orthopaedic Surgery, The University of Tokyo
  4. 4Rehabilitation Services Bureau, National Rehabilitation Center for Persons with Disabilities, Tokyo, Japan


Background Osteoarthritis (OA) and metabolic syndrome (MS) share age and obesity as risk factors. Numerous investigators have associated OA with various components of MS. However, there has been few study clarifying associations between the occurrence or progression of knee OA (KOA) and accumulation of components of MS, using a prospective cohort of general inhabitants.

Objectives To clarify the association between the occurrence and progression of KOA with components of MS, including overweight (OW), hypertension (HT), dyslipidemia (DL), and impaired glucose tolerance (IGT), using a large-scale population cohort entitled ROAD (Research on Osteoarthritis/osteoporosis Against Disability).

Methods Among 1690 participants (596 men, 1094 women; mean age 65.2 years old, range 23–94 years) in mountain and seaside areas from the baseline ROAD study recruited in 2005-2007, 1384 individuals (81.9%; 466 men, 918 women) completed the second survey including knee radiography 3 years later. KOA was defined as Kellgren-Lawrence (KL) grade ≥2 using paired X-ray films. Based on changes in KL grades between the baseline and second survey, cumulative incidence and progression of KOA were determined. OW, HT, DL, and IGT at baseline were assessed using standard criteria.

Results The cumulative incidence of KOA among the 1384 completers over 3 years for the age groups ≤39, 40–49, 50–59, 60–69, 70–79, and ≥80 years was 0.0%, 0.8%, 6.9%, 13.2%, 17.6%, and 25.0%, respectively. Progression in the KL grades for either knee over 3 years was observed in 5.1%, 5.2%, 15.1%, 26.5%, 32.3%, and 49.4% of the participants in these age groups, respectively. Logistic regression analyses after adjusting for age, gender, regional differences, smoking, alcohol consumption, regular exercise, and past history of knee injuries revealed that the odds ratio (OR) for the occurrence of KOA significantly increased according to the number of MS components present (vs. no component; 1 component: OR 2.20; 2 components: OR 2.84; 3 or more components: OR 9.95). Similarly, the logistic regression analysis adjusted for the above variables showed that the OR for progression of KOA in either knee also significantly increased according to the number of MS components present (vs. no component; 1 component: OR 1.38; 2 components: OR 2.31; 3 or more components: OR 2.79).

Conclusions Accumulation of MS components is significantly related to both occurrence and progression of KOA. MS prevention may be useful in reducing future KOA risk.

Disclosure of Interest None Declared

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