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SP0182 Unique contributions of macrophage TIE2 to signalling in RA
  1. K. Reedquist1,2
  1. 1Experimental Immunology
  2. 2Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

Abstract

The angiogenic factors angiopoietin (Ang)-1 and Ang-2, and their shared receptor Tie2, are expressed in rheumatoid arthritis (RA) synovial tissue. Clinical and translational studies have suggested important roles for Ang-1, Ang-2 and Tie2 in the pathology of RA, but the cellular targets of Ang signalling and the specific contributions of Ang-1 and Ang-2 to disease are poorly understood. Here, I discuss recent findings that synovial macrophages are prominent targets of Ang signalling, highlighting the distinct contributions that Ang-1 and Ang-2 make to macrophage activation, the role of macrophage polarization in regulating Tie2 expression and signalling, and evidence that engagement of synovial Tie2 by Ang-1 drives the development of persistent erosive RA in early arthritis patients. Together, these studies suggest a previously unappreciated role for angiogenic macrophage Tie2 signalling in promoting the initiation and persistence of pathology in RA.

Disclosure of Interest None Declared

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