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FRI0269 Three year-follow up of the joint contractures in 131 hungarian patients with systemic sclerosis
  1. Z. Bálint1,
  2. H. Farkas1,
  3. N. Farkas2,
  4. T. Minier1,
  5. G. Kumánovics1,
  6. K. Horváth1,
  7. L. Czirják1,
  8. C. Varjú1
  1. 1Rheumatology and Immunology
  2. 2Institute of Bioanalysis, University of Pécs, Hungary, Pécs, Hungary


Background Musculoskeletal manifestations including arthralgia/arthritis, tendon friction rubs, joint contractures, digital tuft resorption, calcinosis and muscle weakness are the major causes of disability in systemic sclerosis (SSc). Joint involvement has been reported to occur in up to 46% to 97% of SSc patients. Recently complex individualized rehabilitation programs seem to be effective. The optimal therapy for SSc and musculoskeletal symptoms is still not known, and there are only a few joint-observational investigations longer than one year available in the literature.

Objectives To observe the effects of home exercise on changes in range of motion (ROM) and contracture development in a three-year follow-up study in patients with systemic sclerosis.

Methods One hundred and thirty-one consecutive patients, 119 females and 12 males, 41 with diffuse cutaneous SSc (dcSSc), 90 with limited cutaneous SSc (lcSSc) were evaluated at baseline, with 115 patients re-evaluated at 1 and 3 years. Mean age was 55.9±11.6 years (±SD) with a mean disease duration of 8.1±7.2 years. ROM, Modified Rodnan Skin Score (MRSS), Health Assessment Questionnaire (HAQ-DI), Hand Anatomic Index (HAI) and clinical characteristics were recorded. Additionally, every patient at our centre receives instruction for home exercises of hands, mouth and large joints. This cycle is repeated at least every 6 months.

To determine differences between sub-groups Mann-Whitney-U test were performed. Spearman’s Rank Correlation Coefficient was calculated to assess parametric correlation.

Results Limitation in ROM greater than 25% was considered “contracture” and greater than 50% as “severe contracture”.

At baseline, MCP II and III were the most commonly affected joints, in 72-77% of patients. Wrist flexion-extension was impaired in 69-75%, shoulder flexion-extension in 49-50%, PIP II-III flexion-extension in 34-43%, wrist adduction-abduction in 18-22%, knee flexion-extension in 15-17%, shoulder adduction-abduction in 13-15%, rotation in 9-11%, ankle extension-flexion, hip rotation and flexion-extension in 7-8%, abduction in 1-2%.

Over a 3-year-follow up period, differences favouring the non-dominant hand in ROM were statistically significant while there was no difference in laterality of the large joints.

Throughout the follow-up only the small joints (MCPII, III and PIP III) of the hands, the results of the 10-meter walk test and the HAI showed significant improvement. However the large joints, revealed no significant difference. The values of the functional indexes (HAQ-DI and DASH) showed significant improvement (p<0,05) only at the end of the first year in early dcSSc-group.

The number of severe contractures of the upper extremities positively correlated with ESR, C-reactive protein, HAQ-DI and the 10-meter walk test and negatively with forced vital capacity (FVC) at baseline and 3-year-follow up.

Conclusions A simple “routine” stretching exercises performed at home may be beneficial for small joint function, but does not have a noticeable effect on large joint function.The values of the functional indexes, HAQ DI and DASH showed significant improvement only at the end of the first year in early dcSSc-group.Prominent use of the dominant hand may explain its increased impairment in ROM compared to the non-dominant hand.

Disclosure of Interest None Declared

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