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THU0407 Serum ghrelin and obestatin levels in behçet’s disease
  1. S.S. Koca1,
  2. M. Ozgen1,
  3. R. Dayanan2,
  4. M. Kara3,
  5. N. Ilhan4,
  6. A. Isik1
  1. 1Department of Rheumatology, Faculty of Medicine, Firat University
  2. 2Department of Internal Medicine, Faculty of Medicine, Firat University, Elazig, Turkey
  3. 3Department of Medical Genetics, Faculty of Medicine, Firat University, Elazig, Turkey
  4. 4Department of Biochemistry, Faculty of Medicine, Firat University, Elazig, Turkey, Elazig, Turkey

Abstract

Background Ghrelin is a potent endogenous orexigenic peptide controlling food intake and energy expenditure.It is produced by inflammatory cells in addition to gastric cells and mediates anti-inflammatory effects. Moreover, increased ghrelin levels have also been reported in a number of inflammatory diseases.

Objectives To assess serum ghrelin and obestatin levels in patients with Behçet’s disease (BD) and healthy controls (HC).

Methods Fasting blood samples were obtained from 143 patients with BD (whose mean disease duration of 5.3±6.2 years) and 112 HC. Serum acylated ghrelin (AG), unacylated ghrelin (UAG), total ghrelin (TG), and obestatin levels were measured using commercially available ELISA kits.Appropriate statisticaltests were used to analyze the data.

Results Whereas serum obestatin level was significantly higher in the BD group than HC group, there was no significant difference in terms of serum ghrelin levels between the groups (Table). In the active BD subgroup (n=67), serum UAG and TG levels were significantly higher (p=0.040 and p=0.039, respectively), while serum AG level was relatively higher (p=0.098), than inactive BD subgroup (n=76). 12.6% of the BD patients and 20.5% of the HC were obese (p=0.086, odds ratio; 0.56, 95% confidence interval; 0.28-1.09). Serum UAG, TG and obestatin levels were significantly lower in obese subgroup than non-obese subgroup of the BD group (p=0.027, p=0.014 and p=0.001, respectively). In the BD group, age and body mass index were negatively correlated with AG (r=-0.199, p=0.017; r=-0.176, p=0.035), UAG (r=-0.246, p=0.003; r=-0.311, p<0.000), TG (r=-0.322, p=0.003; r=-0.346, p=0.001) and obestatin (r=-0.173, p=0.039; r=-0.250, p=0.003) levels, whereas these correlations were not significant in the HC group.

Table 1. The demographics and the levels of ghrelin and obestatin

Conclusions BD, characterized by a triad of recurrent oral and genital ulcers and uveitis, is a systemic vasculitis of unknown etiology. Serum ghrelin levels were high in active but not in inactive BD patients. These results suggest that ghrelin may play a significant role in the activity BD.

  1. Baatar D, et al. The effects of ghrelin on inflammation and the immune system. Mol Cell Endocrinol. 2011.

  2. Seim I, et al. Ghrelin axis genes, peptides and receptors: recent findings and future challenges. Mol Cell Endocrinol. 2011.

  3. Zhou ZY, et al. Cytokines and Behcet’s Disease. Autoimmun Rev. 2012.

Disclosure of Interest None Declared

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