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SP0119 The aryl hydrocarbon receptor: An interpreter of the micro-environment
  1. M. Veldhoen
  1. Laboratory for Lymphocyte signalling and Development, Babraham Institute, Cambridge, United Kingdom

Abstract

The transcription factor aryl hydrocarbon receptor (AhR) is selectively expressed in some immune cells, importantly in both Th17 and gamma/delta T cells. Its activation is important for optimal development of the Th17 cell subset and results in enhanced activation of both Th17 and IL-17 producing gamma/delta T cells. Immune protection against invading microorganisms starts at epithelial barrier sites. At these sites reside specialised intra-epithelial lymphocytes (IELs) that are important not only as a first line of defence but also in epithelial barrier organisation and wound repair. Especially at epithelial sites, AhR activation in response to endogenous and exogenous ligands may constitute a way in which environmental stimuli could affect the immune status. New data regarding the role of such stimulation will be discussed.

Disclosure of Interest None Declared

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