Lymphoid tissues have an essential role in the induction fo protective immune responses but paradoxically are commonly found associated with autoimmune disease pathology. Development of these tissues occurs as a result of interactions between different types of innate lymphoid cells and underlying mesenchyme which develops into the stroma that supports B and T cell survival. In this lecture comparison between mechanisms driving the development and organisation of different lymphoid tissues including lymph nodes, tonsils, spleen and Peyer’s patches will be discussed. Through understanding the etiology of both normal and pathological tissue formation and organisation novel therapeutics can be developed that selectively modulate the function of lymphoid tissues.
Disclosure of Interest None Declared
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