Background Behçet’s disease (BD) is a systemic vasculitis characterized by a triad of recurrent oral and genital ulcers and uveitis. Although the pathogenesis of BD remains uncertain, immunological abnormalities is mediated by Th1 type derived cytokines in BD. IL-33, from the IL-1 cytokine family, is reported to be increased in various inflammatory diseases including rheumatoid arthritis (RA).
Objectives To assess the serum levels of IL-33 in BD, RA and healthy controls (HC).
Methods Fasting blood samples were obtained from 85 patients with BD, 87 patients with RA and 88 HC. Serum IL-33 levels were measured using commercially available ELISA kit.Appropriate statisticaltests were used to analyze the data.
Results There was no significant difference between the BD and HC groups in terms of serum IL-33 level (p>0.05), while it was lower in the RA group compared to the BD and HC groups (Table, p<0.001 for both). The level of IL-33 was significantly lower in the active BD (n=39) subgroup than inactive BD (n=46) subgroup (11.3±9.3 vs. 13.7±.2 pg/ml, p=0.02).
Conclusions IL-33, also called IL-1F11, induces Th2 responses and exerts anti-inflammatory effects. BD and RA are characterized by a marked shift toward Th1 type phenotype. The serum levels of IL-33, the recently identified cytokine, were decreased in active BD and RA in the present study. These results may suggest the Th1/Th2 imbalance in BD and RA.
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Boissier MC. Cell and cytokine imbalances in rheumatoid synovitis. Joint Bone Spine. 2011.
Miller AM. Role of IL-33 in inflammation and disease. J Inflamm (Lond). 2011.
Disclosure of Interest None Declared
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