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THU0050 Cardiovascular risk in korean patients with rheumatoid arthritis
  1. C.-B. Choi1,
  2. Y.-K. Sung1,
  3. S.-K. Cho1,
  4. S.-Y. Park1,
  5. J. Shim2,
  6. J.J. Kim1,
  7. C.N. Son1,
  8. S.-C. Bae1
  9. and KORONA Investigators
  1. 1Rheumatology, Hanyang University Hospital for Rheumatic Diseases
  2. 2Clinical Research Center for Rheumatoid Arthritis, Seoul, Korea, Republic Of

Abstract

Background Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular diseases and it’s the major cause of death. But, it is unclear if it also applies to the population with relatively low risk for cardiovascular diseases.

Objectives We investigated the cardiovascular risk and their influencing factors in RA patients of Korean population.

Methods Cardiovascular risk in 4,672 Korean RA patients enrolled from 2009 to 2010 in the Korean Observational Study Network for Arthritis (KORONA) cohort were assesed using the Framingham Score and systemic coronary risk evaluation (SCORE) for low cardiovascular risk countries. In KORONA cohort, patients are assessed for demographic characteristics, disease activity, functional status, quality of life, laboratory, and radiographic status. Although laboratory tests including lipid profile is strongly recommended at enrollment, HDL levels were missing in a nimber of patients and they were excluded in assessing the Framingham Score.

Results A total of 1,228 patients were assessed for the Framingham Socre after excluding those with no information on the HDL level. Female constituted 85.8% of the patients and the mean age was 54.7±11.2 years. The mean DAS28-ESR was 3.7±1.3 and mean disease duration was 8.0±7.5 years. Mean Framingham Score was significantly higher in males with 11.6±3.5 compared to 10.7±6.1 in females (p=0.007). It increased with longer disease duration and it was significantly higher in patients with disease duration over 10 years with 12.1±5.1 compared to 10.0±6.2 in those with less than 5 years and 10.5±5.9 in 5 to 10 years (p<0.001).

A total of 4,187 patients were assessed for SCORE for low cardiovascular risk countries. Female constituted 85.4% of the patients and the mean SCORE was significantly higher in male with 3.1±2.8 compared to 0.85±1.2 in females (p<0.001). Longer disease duration was also associated with significant increase in cardiovascular risk. It was more significant when the EULAR recommendations were applied.

Conclusions Korean patients with RA are at increased risk for cardiovascular disease with longer disease duration increasing the risk.

Disclosure of Interest None Declared

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