Article Text

How do contemporary imaging techniques contribute to basic and clinical rheumatology?
  1. Masaru Ishii1,2
  1. 1Laboratory of Cellular Dynamics, WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan
  2. 2Japan Science and Technology Agency, CREST, Tokyo, Japan
  1. Correspondence to Masaru Ishii, Laboratory of Cellular Dynamics, WPI-Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan; mishii{at}


Recent major advances in biomedical imaging techniques have allowed us to visualise a variety of previously unseen biological phenomena. In particular, advanced fluorescent microscopy and radioimaging have enabled us to visualise cellular and molecular dynamics in living animals and humans. These new technologies have identified novel therapeutic targets against a wide array of diseases and have provided novel diagnostic tools for the evaluation of several disease conditions. In this brief review, the author outlines the contemporary imaging techniques used in the fields of immunology and rheumatology, with special focus on intravital fluorescent microscopy, and discusses how these cutting-edge methodologies contribute to clinical practice for patients with rheumatism.

Statistics from


  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.