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Antimalarial ototoxicity: an underdiagnosed complication? A study of spontaneous reports to the French Pharmacovigilance Network
  1. Noemie Jourde-Chiche1,
  2. Julien Mancini2,
  3. Nathalie Dagher3,
  4. Solene Taugourdeau4,
  5. Guillemette Thomas5,
  6. Caroline Brunet4,
  7. Charleric Bornet3,
  8. Marie-Josephe Pastor4,
  9. Laurent Chiche5
  1. 1Department of Nephrology, Hopital de la Conception, Marseille, France
  2. 2Department of Public Health, Hopital de la Timone, Marseille, France
  3. 3Department of Pharmacy, Hopital de la Conception, Marseille, France
  4. 4Department of Pharmacovigilance, Hopital Salvator, Marseille, France
  5. 5Department of Internal Medicine, Hopital de la Conception and the French Pharmacovigilance Network, Marseille, France
  1. Correspondence to Dr Laurent Chiche, Service de Médecine Interne, Centre de Compétence PACA Ouest pour les Maladies Auto-immunes Systémiques, Hôpital de la Conception, 147 Bd Baille, 13005 Marseille, France; laurent.chiche{at}ap-hm.fr

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Antimalarial drugs have been prescribed for years to treat several connective-tissue diseases.1 Epidemiological studies now suggest they may play a role in preventing severe complications in systemic lupus erythematosus (SLE).2 Antimalarial drugs are also used off-label for other systemic autoimmune conditions, including sarcoidosis and Sjögren's syndrome. Indeed, antimalarial drugs are inexpensive and have a good safety profile,3 especially hydroxychloroquine,1 and when systematic monitoring of ophthalmological side-effects is initiated.4 However, some cases of audiovestibular toxicity have been reported anecdotally.5,,7 We conducted this study to evaluate audiovestibular side-effects in patients treated with antimalarial drugs.

All spontaneous reports of audiovestibular adverse events attributed to antimalarial drugs in the French Pharmacovigilance Network database, between January 1986 and …

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