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No impact of serum uric acid on the outcome of recent-onset arthritis
  1. Anna Luczak1,
  2. Rachel Knevel2,
  3. T W J Huizinga2,
  4. Jessica A B van Nies2,
  5. Annette van der Helm-van Mil2,
  6. Jeska Kirsten De Vries-Bouwstra1
  1. 1Department of Rheumatology, Wrocław Medical University, Wrocław, Poland
  2. 2Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
  1. Correspondence to Jeska Kirsten De Vries-Bouwstra, Department of Rheumatology, Leiden University Medical Center, C-01-R, Albinusdreef 2, P.O. Box 9600, 2300 RC Leiden, The Netherlands; j.k.de_vries-bouwstra{at}lumc.nl

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Patients with rheumatoid arthritis (RA) have an almost twofold increase of cardiovascular (CV) mortality and morbidity as compared with the general population and it is thought that chronic inflammation contributes to this association.1 Serum uric acid (SUA) can contribute to low-grade inflammation via increased production of C reactive protein (CRP) and influences cytokine and superoxide production by circulating neutrophils.2 ,3 In RA, higher levels of SUA have been associated with a higher prevalence of CV disease.4 At the joint level, monosodium urate crystals can negatively influence local bone remodelling by excessive osteoclast formation and reduced osteoblast differentiation.5, …

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