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Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study
  1. Lihi Eder1,
  2. Vinod Chandran1,
  3. Fawnda Pellett1,
  4. Sutha Shanmugarajah1,
  5. Cheryl F Rosen2,
  6. Shelley B Bull3,
  7. Dafna D Gladman1
  1. 1Center for Prognosis Studies in the Rheumatic Diseases,Toronto Western Hospital, University of Toronto Psoriatic Arthritis Clinic, Toronto, Canada
  2. 2Department of Dermatology, University of Toronto, University Health Network, Toronto, Canada
  3. 3Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Canada
  1. Correspondence to Dafna D Gladman, University of Toronto Psoriatic Arthritis Clinic, Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto M5T 2S8, Canada; dafna.gladman{at}utoronto.ca

Abstract

Objective A recent population-based study identified several HLA alleles as conferring a risk for psoriatic arthritis (PsA) among patients with psoriasis. The authors aimed to confirm these results using a family-based association study.

Methods PsA probands, psoriasis probands and their first-degree family members were included. All participants were evaluated for the presence of psoriasis and inflammatory arthritis. HLA-B and -C genotyping was performed. The family-based association test was used to test for differences between PsA and psoriasis patients in transmission of candidate alleles from parents to offspring.

Results A total of 178 PsA and 30 psoriasis probands and 561 first degree family members were analysed. The following HLA alleles were over-transmitted to PsA compared with psoriasis: HLA-C*12 (p=0.005), HLA-B*38 (p=0.04), HLA-B*39 (p=0.03), HLA-B*27 (p=0.002).

Conclusions HLA-B*27, HLA-B*38, HLA-B*39 and HLA-C*12 alleles are potential PsA-specific genetic markers among patients with psoriasis.

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Footnotes

  • Funding The Psoriatic Arthritis Program is partly funded by the Arthritis Society, Canadian Institutes of Health Research and the Krembil Foundation.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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