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More than a decade of use of the anti-tumour necrosis factor (anti-TNF) agents in rheumatology has confirmed their acceptable safety profile and very few new rare side effects have emerged. However, TNFα, a pleiotropic cytokine, is important to many physiological functions and its suppression may lead to unexpected consequences. We describe here a rare case of reversible oligoasthenozoospermia in a young patient.
This case concerns a 35-year-old father of a healthy 4-year-old child who was successfully treated for 3 years with adalimumab, a monoclonal human antibody against TNFα, 40 mg subcutaneously every 2 weeks for ankylosing spondylitis (AS). The therapy …