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  • Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets

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Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets
  1. Michael Chen-Xu1,
  2. Ruth Topless1,
  3. Cushla McKinney1,
  4. Marilyn E Merriman1,
  5. Amanda Phipps-Green1,
  6. Nicola Dalbeth2,
  7. Peter J Gow3,
  8. Andrew A Harrison4,
  9. John Highton5,
  10. Peter B Jones2,
  11. Michael Nissen6,
  12. Malcolm D Smith6,
  13. Andre van Rij7,
  14. Greg T Jones7,
  15. Luis Rodriguez-Rodriguez8,
  16. Benjamin Fernandez-Gutierrez8,
  17. María Teruel9,
  18. Alejandro Balsa10,
  19. Dora Pascual-Salcedo10,
  20. Ana M Ortiz8,
  21. Miguel A Gonzalez-Gay11,
  22. Sophia Steer12,
  23. Marthe Maehlen13,
  24. Benedicte Lie14,
  25. B Paul Wordsworth15,
  26. Lisa K Stamp16,
  27. Javier Martin9,
  28. Tony R Merriman1
  1. 1Department of Biochemistry, University of Otago, Dunedin, New Zealand
  2. 2Department of Medicine, University of Auckland, Auckland, New Zealand
  3. 3Department of Rheumatology, Middlemore Hospital, Auckland, New Zealand
  4. 4Department of Medicine, University of Otago, Wellington, New Zealand
  5. 5Department of Medicine, University of Otago, Dunedin, New Zealand
  6. 6Department of Medicine, Flinders Medical Centre and Repatriation General Hospital, Adelaide, South Australia, Australia
  7. 7Department of Surgery, University of Otago, Dunedin, New Zealand
  8. 8Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain
  9. 9Cellular Biology and Immunology Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain
  10. 10Department of Rheumatology, Hospital La Paz, Madrid, Spain
  11. 11Department of Rheumatology, Hospital Marques de Valdecilla, Santander, Spain
  12. 12Department of Rheumatology, Kings College Hospital NHS Foundation Trust, London, UK
  13. 13Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
  14. 14Institute of Immunology, University of Oslo, Oslo University Hospital, Rikshospitalet, Oslo, Norway
  15. 15Nuffield Department of Orthopaedic Surgery, NIHR Oxford Musculoskeletal Biomedical Research Unit and Botnar Research Centre, University of Oxford, Oxford, UK
  16. 16Department of Medicine, University of Otago, Christchurch, New Zealand
  1. Correspondence to Dr Tony Merriman, Department of Biochemistry, 710 Cumberland Street, University of Otago, Dunedin, New Zealand; tony.merriman{at}otago.ac.nz

https://doi.org/10.1136/annrheumdis-2011-200591

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    The IL-23R region is associated with a number of non-infectious inflammatory conditions including inflammatory bowel disease, ankylosing spondylitis and psoriasis,1,–,3 and albeit with less consistent evidence, rheumatoid arthritis (RA).4,–,6 Association of rs1343151 (G→A) with RA, but not rs1004819/rs10489629/rs2201841, has been reported in European and New Zealand sample sets;5 none of rs3212227/rs6887695/rs7530511 was associated in European and North American sample sets,6 and rs7517847 was not associated in meta-analysed European and New Zealand sample sets.4 Given the immunological evidence pointing to the importance of the Th17–IL-23 axis in inflammation and autoimmunity,7 and the unresolved question of whether or not IL-23R is associated with RA, we further investigated association of IL-23R with RA in white European Caucasian case–control sample sets (cases ascertained …

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    Footnotes

    • Funding The study was funded by Health Research Council of New Zealand.

    • Competing interests None.

    • Ethics approval The study was approved by the Madrid and Lugo hospital ethics committees, The Regional Committees for Research Ethics in Eastern and Southern Norway, Multi-region Ethics Committee and the Lower South Ethics Committee of New Zealand, the Lewisham Hospital and Guy's and St Thomas' Hospitals local research ethics committees, The Oxford Research Ethics Committee.

    • Provenance and peer review Not commissioned; externally peer reviewed.