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Very few studies have reported radiographic improvement of damaged joints in patients with juvenile idiopathic arthritis (JIA) following treatment with biological response modifiers.1 We previously reported the efficacy and safety of tocilizumab, an anti-interleukin 6 receptor monoclonal antibody, in patients with systemic-onset JIA.2,–,4 In the present study, we investigated remodelling characteristics of damaged large joints, especially weight-bearing joints, by radiographic examination following tocilizumab treatment for 5 years.
Seven patients (two female and five male) with systemic-onset JIA, receiving 8 mg/kg of tocilizumab intravenously every 2 weeks, were …
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