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Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population
  1. Xiaolan Lu1,
  2. Jianping Guo1,
  3. Xujie Zhou2,
  4. Ru Li1,
  5. Xia Liu3,
  6. Yi Zhao4,
  7. Baoli Zhu5,
  8. Xiangyuan Liu6,
  9. Jianhua Xu7,
  10. Ping Zhu8,
  11. Xinyu Wu1,
  12. Jing He1,
  13. Xu Liu1,
  14. Hong Zhang2,
  15. Zhanguo Li1
  1. 1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
  2. 2Renal division, Peking University First Hospital, Peking University Institute of Nephrology, and Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
  3. 3Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China
  4. 4Department of Rheumatology, Xuanwu Hospital, Beijing, China
  5. 5Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
  6. 6Department of Rheumatology, Peking University Third Hospital, Beijing, China
  7. 7Department of Rheumatology, Anhui Medical University First Hospital, Hefei, China
  8. 8Department of Clinical Immunology, Xijing Hospital of Fourth Military Medical University, Xi'an, China
  1. Correspondence to Zhanguo Li, Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing 100044, China; lxlu{at}bjmu.edu.cn

Abstract

Objectives The deletion of LCE3C_LCE3B confers susceptibility to psoriasis and rheumatoid arthritis (RA) in Caucasians. The aim of this study was to investigate the variant involvement in RA in the Chinese Han population and to further explore its potential role in the susceptibility to systemic lupus erythematosus (SLE).

Methods LCE3C_LCE3B-del was genotyped in 898 patients with RA and 681 healthy controls. Two single nucleotide polymorphisms (SNPs, rs4112788 and rs4085613) in strong linkage disequilibrium with LCE3C_LCE3B-del were then genotyped in patients with RA (n=1222), SLE (n=870) and healthy controls (n=1031).

Results The deletion of LCE3C_LCE3B and SNPs rs4112788 and rs4085613 showed an association with RA (allele analysis: p=7.72×10−4, OR 1.28, 95% CI 1.11 to 1.47; p=6.39×10−4, OR 1.23, 95% CI 1.09 to 1.38; and p=5.38×10−4, OR 1.23, 95% CI 1.10 to 1.39, respectively). The two SNPs were also significantly associated with SLE (allele analysis: p=7.68×10−3, OR 1.19, 95% CI 1.05 to 1.36 and p=5.30×10−3, OR 1.20, 95% CI 1.06 to 1.37).

Conclusions This study provides evidence for an association between LCE3C_LCE3B-del and RA in non-Caucasian populations, and SNPs rs4112788 and rs4085613 tagging LCE3C_LCE3B-del were novel susceptibility factors for SLE.

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Footnotes

  • XL and JG contributed equally to this work

  • Funding This work was supported by the Major State Basic Research Development Program of China (973 Program) (No. 2010CB529100), General Program of the National Natural Science Foundation of China (No. 30972710) and Beijing Science and Technology Star Plans (No. 2007A011).

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the Peking University People's Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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