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Association between focal erosions and generalised bone loss in psoriatic arthritis
  1. A P Anandarajah1,
  2. M El-Taha2,
  3. C Peng2,
  4. G Reed3,
  5. J D Greenberg4,
  6. C T Ritchlin1
  1. 1Clinical Immunology Research Center, Allergy, Immunology and Rheumatology Research Division, University of Rochester Medical Center, Rochester, New York, USA
  2. 2University of Southern Maine, Department of Mathematics and Statistics, Maine, USA
  3. 3University of Massachusetts, Department of Medicine, Massachusetts, USA
  4. 4NYU Hospital for Joint Diseases, Division of Rheumatology, New York, USA
  1. Correspondence to A P Anandarajah, Clinical Immunology Research Center, Allergy, Immunology and Rheumatology Research Division, University of Rochester Medical Center, 601 Elmwood Avenue, P O Box 695, Rochester, NY 14642, USA; allen_anandarajah{at}urmc.rochester.edu

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Bone erosions are frequent in patients with psoriatic arthritis (PsA) but the prevalence of generalised bone loss in PsA is not well understood.1,,6 To formally address this question, we analysed data from the Consortium of Rheumatology Researchers of North America registry.

Erosions on plain x-rays of hands and feet and T-scores at the lumbar spine, femoral neck and total hip were identified as the key outcome variables. Key independent variables included gender, age, weight, C reactive protein, functional status, Health Assessment Questionnaire, body mass index and medication use. Medications included methotrexate, other disease-modifying antirheumatic drugs (DMARDs), anti-tumour necrosis factor (anti-TNF) agents, prednisone use (yes or no) and prednisone dose …

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