Statistics from Altmetric.com
Ankylosing spondylitis (AS) is an inflammatory rheumatic disease and strongly associated with human leucocyte antigen (HLA)-B27.1 A genome-wide scan for AS revealed the linkage locus on many non-major histocompatibility complex (MHC) loci of chromosomes.2,–,5 Among all non-MHC regions, we examined an 11cM region 16q23.1-24.1, with two announced positive STR markers: D16S515 and D16S516. Among the 101 genes in this region, proteasome 26S subunit non-ATPase 7 (PSMD7) was chosen as the only candidate gene because of its importance in the ubiquitin proteasome pathway (UPP). The UPP genes have been much studied in AS studies. Two MHC UPP genes: LMP2 and LMP7 were found to be associated with AS in Caucasian and Chinese populations.6,–,8 Two recent reports found that protein or gene expression levels of some UPP subunits were higher …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.