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Primary Sjögren's syndrome (pSS) is characterised clinically by sicca symptoms of the eyes and mouth. However, a proportion of pSS patients also present with extraglandular symptoms, for which immunosuppressive treatments may be needed. An expert panel of the European League Against Rheumatism (EULAR) has very recently developed a EULAR Sjögren's syndrome disease activity index (ESSDAI) to evaluate these systemic symptoms of pSS.1 The index consists of 12 organ-specific domains, which are predominantly clinical; only 2 of them include haematological (cytopenias) or biological (clonal component, serum complement levels, serum IgG and cryoglobulins) findings.1
β2 Microglobulin is a low-molecular weight (11.8 kDa) polypeptide protein, which is one of the major histocompatibility class I molecules on the cell surfaces of all nucleated cells and is produced in particular by lymphocytes. We have previously reported that serum β …
Footnotes
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Funding This study was financially supported by the Competitive Research Funding of Tampere University Hospital, Tampere, Finland, and the Tampere Tuberculosis Foundation.
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Ethics approval The study has been approved by the Ethical Committee of Tampere University Hospital, Tampere, Finland.
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Provenance and peer review Not commissioned; externally peer reviewed.