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Ann Rheum Dis 70:2052-2054 doi:10.1136/ard.2010.145672
  • Letters

Adiponectin and leptin increase IL-8 production in human chondrocytes

  1. Oreste Gualillo1
  1. 1SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela, Spain
  2. 2SERGAS, Research Laboratory 7, Molecular and Cellular Cardiology, Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela, Spain
  1. Correspondence to Dr Oreste Gualillo, SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Travesia Choupana s/n, Building C, Level -2, Santiago de Compostela 15706, Spain; oreste.gualillo{at}sergas.es
  1. Contributors RG participated in acquisition of data, analysis and interpretation of data and critical revision of the manuscript. MS and JC participated in acquisition of data, drafting of the manuscript and statistical analysis. JJG-R participated in analysis and interpretation of data and drafting of the manuscript. FL participated in analysis and interpretation of data, critical revision of the manuscript and scientific supervision of experiments. OG participated in conception and design of the study, in analysis and interpretation of data, critical revision of the manuscript and scientific supervision of experiments.

  • Accepted 23 April 2011
  • Published Online First 29 May 2011

Rheumatoid arthritis (RA) and osteoarthritis (OA) are two of the most frequent articular diseases. Recently, adipokines have been proposed as relevant mediators of cartilage degeneration in both OA and RA.1 Our group has previously demonstrated that RA patients have elevated serum levels of leptin and adiponectin,2 while others have shown positive associations between serum levels of leptin and hip-radiographic OA,3 and of adiponectin and erosive OA.4 Thus, several studies have suggested that adipokines can modulate the …

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