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Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype
  1. P Hindryckx1,
  2. D Laukens1,
  3. G Serry3,
  4. L Van Praet2,
  5. C Cuvelier4,
  6. H Mielants2,
  7. H Peeters1,
  8. D Elewaut2,
  9. M De Vos1
  1. 1Department of Gastroenterology, Ghent University, Ghent, Belgium
  2. 2Department of Internal Medicine, Ghent University, Ghent, Belgium
  3. 3Department of Pathology, Ghent University, Ghent, Belgium
  4. 4Department of Rheumatology, Ghent University, Ghent, Belgium
  1. Correspondence to Dr D Elewaut, Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium; dirk.elewaut{at}ugent.be

Abstract

Background Vascular endothelial growth factor (VEGF-A) and placental growth factor (PlGF) are major regulators of pathological angiogenesis, which is a prominent feature of both Crohn's disease (CD) and peripheral synovitis in spondyloarthritis.

Objective To investigate the presence of VEGF-A and PlGF in the gut of spondyloarthritis patients and to link this finding with subclinical gut inflammation in these patients.

Methods Intestinal biopsies from healthy controls, CD patients, spondyloarthritis patients with or without subclinical gut inflammation and rheumatoid arthritis (RA) patients were stained for VEGF-A, PlGF, CD31 and vascular cell adhesion molecule 1 (VCAM-1) and digitally analysed.

Results Spondyloarthritis patients with subclinical gut inflammation had markedly increased intestinal VEGF-A expression (p<0.001), mucosal vascularisation (p<0.001) and VCAM-1 expression (p<0.01) compared with healthy controls and RA patients, which, unlike in CD patients, was also seen when the gut inflammation was in a quiescent state. PlGF expression was highly increased in the subclinically inflamed gut of spondyloarthritis (p<0.01 compared with healthy controls), but not at all in CD.

Conclusion A pro-angiogenic intestinal phenotype is observed in spondyloarthritis patients with quiescent chronic gut inflammation. This favours an environment for enhanced trafficking of immune cells in this subpopulation.

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Footnotes

  • Funding This study was supported by the concerted grant GOA2001/12051501 of Ghent University, Belgium, and by a grant of the National Fund for Scientific Research to PH (FWO grant A2/5-11716).

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the institutional review board of the Ghent University Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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